01 / RESEARCH
ACLF and decompensated cirrhosis
Defining disease turning points and how precipitants and organ-failure patterns shape short-term outcomes.
ACLFCirrhosisClinical trajectories
RESEARCH / 研究方向
From clinical trajectories to disease mechanisms.
Connecting clinical cohorts, immune mechanisms, biomarkers, and multi-omics across the course of severe liver disease.
02 / RESEARCH
Natural history and dynamic prediction
Using longitudinal measurements and multistate models to turn static scores into updateable trajectory estimates.
Longitudinal cohortsRisk stratificationPrediction
03 / RESEARCH
Inflammation, immune dysregulation, and resolution
Combining single-cell and spatial omics to identify cellular and molecular programs that drive progression or promote resolution.
ImmunologySingle-cellSpatial omics
04 / RESEARCH
Infection in cirrhosis and liver failure
Studying links between infection recognition, host response, and organ decompensation to improve early stratification.
InfectionHost responseOrgan failure
05 / RESEARCH
Biomarkers and multi-omics translation
Discovering clinically testable diagnostic and prognostic signals across metabolomics, transcriptomics, and phenotypes.
BiomarkersMetabolomicsTranslation
06 / RESEARCH
MASLD, metabolic risk, and chronic liver disease outcomes
Studying long-term outcomes in hepatitis B and MASLD. Multicenter longitudinal cohorts examine how weight trajectories and changes in obesity status relate to liver stiffness and liver-related events, alongside associations between antidiabetic drug classes and liver outcomes in people with type 2 diabetes and MASLD.
HBVMASLDWeight trajectoriesMetabolic therapies and outcomesLiver-related events